Cancer Smelling Dogs, Nuking Mars, Steroid Olympics, and Longevity Hacks
New episode: Cancer Smelling Dogs, Nuking Mars, Steroid Olympics, and Longevity Hacks. Listen on Spotify or watch on YouTube.
They came out. first they came out and said it wasn't real and now apparently JP Morgan is doing a million-doll like I don't know settlement or something to try to avoid going to trial. So I something is going on obviously something's fishy. >> Yeah, something happened. But you know this this guy you you look at the the pictures and the story and the description of what happened in the trial >> and the stuff that the guy this guy says, >> you know, it's just like absurd.
I like I don't know you know in one sense you don't want to discount what a potential victim is saying right >> but it just also seems so absurd that you know when the more details came out >> apparently that lady you know Lorna Hajini I think was her name and then this guy they're on the same team like she's not his supervisor which was one of the main premises initially in the complaint that >> she had power to ruin his career promotion ability whatever it was so I mean That was false.
And you know, that's kind of what everything's predicated on. If they if there wasn't a power dynamic, then I mean, >> yeah, he wasn't working directly under her. >> Yeah, exactly. I I don't know. My my theory is that I don't know. The they were having an affair and the guy was cheating on his wife and they found out and to try to save face, he started this scandal. But I I don't know. >> No, my theory is that this guy was doing something very illegal or or she was doing something very illegal.
And um you know they he was threatened to be fired and then he came up with this this story and this idea and then started uh threatening them uh so he doesn't get indicted or caught and now they're just paying off paying him a million dollars to u to be quiet. >> Yeah. The funniest thing is is like the memes, you know, like when it first came out, there's so many memes of like people running like to sign up to be JP Morgan interns.
And >> apparently like the chick shut down her LinkedIn cuz she was getting so many DMs of like people asking to be hired by her. >> The internet is is undefeated, but it's just so funny. But but the account of the story like him just the sentences and the words like him saying the stuff that she said to him is straight out of a like you know one of those adult >> it's like a '9s comedy movie is like some of the lines I mean like fish head. I mean I didn't I've never even heard of that before.
Like is that a real derogatory term or is that just made up? I was like >> apparently that's a that's a term for to like insult Asians but uh >> you've never even heard of it before. I've never heard of it, but you know, who who knows? I mean, there's a lot of crazy stuff going on. >> I know. And then he was apparently allegedly saying like she's said that his I I don't even know his wife or girlfriend or whatever like has small breasts. That was one thing.
And she's like doesn't have cannons like these? Like who talks like that? Oh man, it cracked me up. I was dying laughing when I read this. One of my friends sent it to me like when the story first broke. And dude, I was cracking up. I was I was sitting in like clinic in between patients and I was like, "Oh my god, this is absurd." And the resident was sitting next to me and I was like, "Dude, look at this. Have you heard of this story? This is like happening right now. This is absurd." >> Yeah.
>> Oh man. >> I mean, at first at first they didn't release the the the images or pictures or names of the people that are involved. >> Yeah. Yeah. >> Then they released the picture of the guy and but it's kind of sad, you know, if this was this was flipped in a way like uh that would be much more believable in >> like if the genders were flipped. >> The genders were flipped. People would definitely jump on it and it would be a big uh people would believe the victim more in this case.
Uh because the guy is a victim this time. >> Uh people are not really believing him. But the story is also very unbelievable. >> Yeah, the story is absurd too. But I mean I I agree with you. I think if the if the genders were flipped um people are more likely to believe that I guess you know a man would abuse his power um for sexual favors rather than a woman abusing her power. But I could happen either way. >> Yeah man. You know like uh the world has become such a place full of drifters.
You know, there's so many people just trying to scam out of the way, trying to make quick money, you know, lo leaving all their ethics around, you know, behind them and kind of just trying to find shortcuts to wealth, >> right? >> Big buck. Yeah, >> big buck. And that brings us to like this big story that broke uh recently uh by uh you know uh there's a substag uh and the story broke about the miracle treatment that almost killed them.
You know, it's a pretty interesting story about Mark Hyman uh and Jordan B. Peterson and this doctor named Adil Khan. Uh did you read that story? Right. >> Yeah, man. I mean, it's, you know, it's crazy because Mark Heyman and Peterson are two very famous podcasters and, you know, Heyman especially, has written a bunch of books and he's big in this whole longevity wellness space, which we've talked about on a few episodes now.
And you know they're both patients of this one doctor Adil Khan who you know he builds himself he's a Canadian trained MD um and he builds himself as this not only wellness but like real regenerative and functional medicine guru and expert who's an expert in stem cell treatment injections into joints into you know spinal spaces and stuff to improve disc degeneration improve stenosis improve arthritis a bunch of stuff like that And um apparently as the story goes he injected Heyman into Heyman's epidural space.
Epidural space meaning the space around your spinal canal your spinal cord. Uh which is a very immune privileged space. That's where the cerebral spinal fluid is is continuous with your brain. U he injected that space with this cocktail of meenal stem cells and exoomes. Um and apparently Hyman and this is alleged but it was in the substack. Apparently, Heyman developed a huge epidural abscess from that and nearly died.
Um, and it's funny because he has spat in the face of conventional traditional real medicine his whole career. That's kind of what's given him his platform and his claim to fame. >> And now he had this happen and what happened? He had to go to a real hospital and have real emergency neurosurgery to evacuate this abscess from this basically farcical treatment that he has touted himself. And I mean there's a lot to unpack there. A lot of >> conflict. There's a lot of different things to unpack.
So you know this guy Mark Heyman, I mean he's known as functional medicine. This functional medicine has become this huge talking point and >> like what what the hell is functional medicine? >> Yeah. I mean they have certifications. People are you know there's people not real not practicing physicians but uh non-MDs or DOS uh that are taking a lot of these functional medicine courses.
some MDs as well and some MDs and DOS as well, but they're taking these functional medicine courses and it kind of, you know, um it's it's easy to sell yourself. Hey, like you know, I'm not a doctor that likes medicine and giving you all these pharmaceutical pills. I I like giving you natural therapies. I like giving you supplements. That's that come to me. And I think uh doctors are making you sick. And this this cure to you is this supplement that I made is is named after me.
And I combined all these these different uh vitamin B12 with L3ine and whatnot. And this will help save your life and decrease your inflammation. I mean, functional medicine just keeps talking about inflammation. And I can't tell you that the rise of that language and that those talking points over the past few years. I mean, I've seen it.
You know, as more and more people have started listening to podcasts and, you know, doing their own research online, uh these these these these terms keep coming up. Oh, I want to reduce my inflammation. I have uh you know, I'm very inflammatory. I have I'm taking these supplements. I need something. >> It is. It is very inflammatory. >> Yeah. >> Their whole premise is inflammatory in my opinion. But >> yeah, whole premise is inflammatory.
There's no research, no randomized control trials, no large patient data behind it, right? Uh no no real proof that this really medicine works. I mean, a lot of the patients show up with all these elaborate tests for $600, $700 that they've done on their gut biome, and they show up and they said, "This is, you know, I'm I'm I'm deficient in zinc and um LP767 in my gut, whatever. I'm just making words up now.
Yeah, it might as well be." And then you see look at these results and you see this elaborate report. It looks fancy and nice and seems like it's it's something, but where's the action? What does it truly mean? And then they have all these people telling them, hey, to to to help with these deficiencies that we just found nutritionally in your body, take this supplement that who knows what's in there to help yourself.
And this is kind of what Mark Heyman has been pushing for all these years, right? He he pushes all these uh um French testing um supplements and weird longevity routines and he has a big podcast a lot of people listen to over thousand plus episodes >> are super popular. I mean he's written like 12 books that are all bestsellers.
I obviously the guy is great at marketing himself, but >> I mean his whole premise and model in my mind very simply is come up with a bunch of these I mean whatever these fake or pseudocience diagnostic algorithms and a bunch of tests just so that it justifies him selling you the products that he brands and that he makes money off of directly. And not just him, there's others too. I mean we're just singing him out because this was in the news story. But I mean this is not evidence-based.
This is not real validated reproduced science across the board. I mean this is >> you can call it fringe. Some people would call it cutting edge to put a positive spin on it. I mean the the fact of the matter is we just don't know. You don't know what the efficacy is meaning the positive benefit of something and the side effect profile and they're not studies that are done in a longitudinal basis. There's not randomization. You don't have long-term data on it.
So I mean it is it's experimental and people should just come out and say it. There's nothing wrong with experimental treatment, but you should be forthcoming about it rather than pitching it from the angle that somehow I am above the rest and have found some new thing, some new secret. Come to me, give me your money and I will share my secret medicine with you. But this is an example, right? These guys are so what they do is they they say that they take these supplements.
They're doing this on their own bodies. So yeah, you should do it too. First, number one, um you know, I don't trust people who um are are benefiting uh from other people taking a certain medication, right? In terms of as physicians or doctors, if you're a doctor and your main source of income is motivated by a patient taking that medication that you're selling and every time you sell a pill and give a patient a pill, you make profit.
And that just the incentive motive is just misaligned there, right? First thing is that. The second thing is they're very forthcoming about the benefits of what they're doing and you know uh their sauna routine and their cold plunging routine and the supplements they're taking and they'll sell that. But then stuff like this when something like this happens they completely hide it. So Mark Heyman has been very quiet about it. He has not talked about what really happened.
Um >> and even even beyond being quiet about it. I mean, he's tried to hide it, right? Like, I think the one of the only, if the only podcast episode he's had that he has deleted completely is his episode with that doctor, Adil Khan. Like, that episode is gone now. >> Yeah. So, he disappeared for 6 months. No one knew where he was. Yeah. He was probably sick, suffering from sepsis from this epidural. >> He may be in an ICU. >> Yeah.
And then he returned on the first episode he did uh uh you know, was returning on J Shetty's podcast. talk about another, you know, um, guy, uh, that's kind of in a similar realm, I feel. >> He's a good public speaker, though. I'll give him that. >> Yeah, a good speaker. I mean, I mean, they're famous because they're skilled. You know, they can talk and they can have a good conversation and they can make people believe themselves.
uh but you know he he appeared on the podcast and just you know kind of even was asked about the whole episode of Dil Khan and has been very vague about it over the years and uh where I mean but uh uh the the Carney article kind of uncovered the UCSF uh records where um you know he was treated for emergency surgery apparently for the epiduralis and in the end conventional medicine had to save him everything that he's been talking about longevity and supplements and keeping living forever.
Uh conventional medicine, actual doctors saving his life in the ICU, preventing uh him from getting paralyzed forever. Uh leg down, you know, waist down. Um that's what came in play then, right? >> Yeah, for sure.
And you know that's like I mean on the one hand you know if you just look at it purely from you know a business marketing standpoint if you eliminate like the ethics of medicine you know these guys like Mark Hman Jordan Peterson Adil Khan and many others a lot of these so-called wellness influencers functional medicine regenerative medicine people I mean they're doing great for themselves better than any physician who practices real medicine. I mean they have an excellent marketing strategy.
They're getting their voice out via podcasts interviews books. YouTube shorts. I mean, the whole deal, right? They're creating products, their own brand or they're partnering with other brands and they're selling it. So, I mean, they they're very successful businessmen and very successful marketers. That's no question about it.
I I think the the challenge is when people come to you, your customers who still view themselves as a patient and they view it as like still a healthcare relationship, like a doctor physician relationship in some way rather than just going to GNC and picking up a new bottle of zinc or a new bottle of magnesium. It's different when it's coming from a doctor who is using their medical expertise.
They're, you know, on paper board certification, whatever it is, and they're using that to justify that this is somehow legitimate and it is somehow validated and science-based. I think that's that's where the real danger comes in and people exploit that. I mean, human nature is that I mean there's people like that in every industry. >> Yeah. I mean, most doctors are, you know, confined by a lot of regulatory agencies, right?
I mean um we as uh physicians uh should practice medicine that's guideline based and evidence-based right not not always guideline based but evidence-based guidelines are slow usually but evidence-based medicine is very important you have to use evidence to be able to tell patients hey this works this does not work right that's one thing the second thing is we're confined by the laws of the country and you know things have to be FDA approved for us to recommend them right we cannot just approve and recommend things that are not approved by the FDA are not tested.
Uh and that's why Adil Khan like you know he does not have clinics in the United States. He he practices in Cabo Mexico in Dubai in Japan where the same regulatory conditions do not apply. There's a reason because a lot of the stuff that he does is is not approved by the FDA or any regulatory agency and has not gone through the testing. That's why he has to go um to other countries.
He he gives free treatments to a lot of celebrity guests that can come into his his clinics and post about it and and then that's how he gets a lot of other rich people to uh pay for his for his treatments, right? >> Yeah. And so like you know to talk about him for for a sec, you know, so Adil Khan he's a real doctor. He has an MD. He's Canadian trained, board certified. I believe it was family medicine or something like that.
um was his specialty and you know he got into this regenerative medicine space and one of his big claims to fame is the the whole premise of muse cells um these special types of differentiated pur potent stem cells that primarily come from the bone marrow and can become like basically any cell lineage. That's what pur potent means. and he worked directly with the person that first discovered these.
And so that that gives him some legitimacy in this whole world of regenerative medicine that he's kind of like the first person to commercialize this that you can do, you know, bone marrow aspirates or whatever have you and now inject these muse cells and they can have very beneficial regenerative effects. That that's the premise behind it, right? And there there is a lot of invivo and in vitro studies on muse cells specifically. Um, so it's not that it's all farce.
It's just I think kind of what you're talking about, the way that he's going about it, like almost like definitively saying that this is going to help you, this is proven, but it's kind of like track record versus real scientific evidence are two very different things. and you know like giving free treatment as almost like a sponsorship um to celebrities and famous influencers and Instagram personalities so that they can post about your product and give you legitimacy, right?
You get social proof that way just like Coca-Cola will give you lifetime supply if you're on in their commercials. You know what I mean? But that will make other people buy Coca-Cola. Um it's the same thing with this stuff. You know, people see on Instagram and Twitter and all this stuff. Kim Kardashian posting about how she went to see Adil Khan at his clinic in Mexico. Zack Efron went and saw the same doctor at one of his clinics and joined like a membership premiere program.
Chris Hemsworth went and saw him in Dubai um to do the same stuff, right? And so, you know, these are real celebrities that are role models for people.
And when you use that and you know this funny if you look up this guy there's a bunch of Reddit posts um and people that have gone to his clinics and gotten consultations with him and it's not just him it's a bunch of other doctors that he works with or they work under him and he he's kind of like the face of it but a lot of them do more of the treatments and some of the treatments the cash pay price that people are posting on Reddit that they're being charged like 18,000 bucks for an exoome injection 6,000 bucks for an individual like stem cell injection.
Crazy prices, dude. Crazy prices. All >> cash. >> Yeah. I mean, definitely. That's that's crazy, right? $18,000 just and mostly it is a is it is a rich people treatment. A lot of people who can afford it can can throw away $18,000 for some kind of experimental therapy. I mean, yeah, you're right. I mean, there are some studies uh that have shown benefits. I mean, there's one case study, right? Uh a first human report with some some relief in with the epidural MSC injection.
There's some 10 patient trial from Mayo Clinic that showed some mild benefits as well, but it was a very early small control trial in a small setting, right? Um, but in the end, do we know that can we can we recommend and can we as a as as someone uh who has sworn like you know do no harm. Um, can I recommend that to patient and be sure that the benefit the potential benefit from this outweighs any kind of harm that it caused? Right?
you know there's a 5 to 31% uh incidence of uh some kind of complications and and any one who gets these infection there's around more than 20% chance of getting back spasms a UTI or some kind of you know muscle neuropathic pain from these you can you can injure nerves as well so a 20% risk of getting UTI is that and maybe even leading to an absis uh that Markman got is that worth it right is that worth the risk And we don't know unless you do large scale trials to kind of prove that this works that if you start doing this and this becomes more affordable and more people do start doing it for a cheap cost and everyone starts flocks to these clinics uh the amount of harm we can do and number of people that could be kind of disastrous and you know could be bad.
>> Yeah, for sure. I mean, you know, my my thought on it is kind of split a little bit. Like on the one sense, you know, if you've got the money to pay for it, who is anyone else to stop you from doing it, right? You're >> in one sense, you're harming or maybe not harming. I mean, who knows? Like, who knows in 10 years some of this stuff, muse therapy may be just as prevalent as PRP is today, which when PRP first came about, it wasn't allowed to be done in the US.
Like, athletes were going to Europe and Germany. And I think, you know, Kobe was famous for stuff like that that he was going to Germany for procedures and everyone thought it was quackery and turn it was very legitimate. I mean, it's done with great evidence today. I don't know. I'm not going to go out and claim all this is BS.
I just think like the way that it's being done by, you know, these influencer doctors rather than in a legitimate scientific process as the first step makes me automatically skeptical. And I think it should make everyone automatically skeptable because of the financial conflicts that you talked about, >> but that doesn't mean it's nonsense. I just think like it needs legitimacy in real studies.
And if you're rich enough and want to go fly to Japan or Dubai or wherever and go get these treatments because you believe in it, you have read whatever science exists and you believe in it, I mean, go do it. But you're accepting the risk, right? And I think that's that's a huge factor. It's not your traditional medical liability thing. I mean, this is obviously outside the realm of FDA and all of that stuff.
>> I agree with that and definitely we need to have an open mind about any cutting edge treatments like this, right? But if if if you're looking at 10 patients that you're going to inject with this and out of them maybe two would really significantly benefit, but five of them will get significant UTI with epidural uh you know infections or sepsis. >> Is that truly worth it? Yeah, some things could work, but does uh the the the risk of it outweighs the benefit or benefit outweighs the risk?
We don't know that. We won't know that until we do some clinical trials, right? And that's one of the big reasons we wanted to do this podcast that uh you know hopefully people will start listening to one day is uh you know that we wanted to have real physician voices out there um because there's a lot of non-f physicians a lot of quacks that are out there seeing a lot of making a lot of claims.
I always thought it was a good idea that actual real doctors that are practicing, seeing patients, seeing 25, 30 patients a day, 40 patients a day, treating patients in the hospital, saving lives are the ones coming on and talking. And that's one of the goals we had when we started this podcast and um you know to kind of spread information about this and what when people always have these questions and now it's become easy for me.
A lot of times people ask me questions about peptides, I tell them, "Hey, go watch this episode." Or people ask me questions about exercise. And now people will ask me questions about MSC injections for the spine. I can be like, "Hey, go listen to this episode." >> Yeah, there you go. >> The other the other other question I get a lot is uh you know about testosterone therapy and that uh you know uh or performance-enhancing drugs and what kind of effect they have on the heart.
And the other interesting story is this new enhanced games that's that's starting in a couple of weeks in Las Vegas. uh you know this is pretty much uh Olympics uh or some kind of you know >> doped up Olympics basically. >> Yeah, drugged up Olympics where there's a bunch of different sports like swimming and gymnastics and whatnot and wrestling. Um but uh with uh people are able to use performance-enhancing drugs that are FDA approved.
So it's it's kind of interesting concept you know it's under physician supervision. There's athletes that are planning on injecting themselves and making sure they're at peak performance, you know, optimizing their bodies. Kind of along the same line, right? Like people, the Mark Heymans of the world, um, uh, they they always talk about longevity and optimizing their body, doing certain things. It's the same idea.
These humans that are highly athletic already using drugs to further enhance their bodies. Um, and there's people in involved like Brian Johnson who's another longevity expert like or expert like uh Mark Heyman. Um, that's >> he's an expert in the same like honestly like completely BS way that hey I do XYZ and I believe I'm super healthy. Therefore, I'm going to sell my supplements and everyone should do it.
You know, using themsel as the guinea pig, your N equals one sample size and somehow that's legitimate enough to make a brand of supplements. And I mean, remarkably it works. Like the guy makes a ton of money off selling his like his crap stack of a bunch of different supplements. >> Yeah. So >> crazy. I mean he like he like gets blood transfusions from his 18-year-old son to be young. I mean he just he's like a lunatic. >> There was a there was like a long form article written about that guy.
I forget in what like New York Times or something like that about his daily routine. He like >> I mean it's so regimented it's absurd. like his entire life is set around trying to just live forever, which sorry to break it to you. Ain't going to happen. >> It's not going to happen, bro. >> Yeah. I mean, hundreds of supplements a day, waking up at a certain time. >> Uh, you know what? Not optimizing body temperatures, whatnot. So, yeah.
I mean, it's I think and I'm sure he knows that he's not going to live forever, too. He is going to die. Everyone dies. Uh, but it's probably a very good money maker right now, and that's why he's doing it, right? For sure. I think this enhanced games idea is kind of interesting in a way. You know, it's funny like when I was a kid, like I don't know, a teenager, I would always joke with my friends that like, dude, wouldn't it be cool if they just allowed steroids in sports, you know?
It's like almost all the athletes in some sports, like not every sport, but in a lot of sports are using some performance-enhancing drugs anyways. >> Uh like I had a professor in med school who he worked at the Olympic training center. He was a PhD biochemist and he was basically like very open. He's like, "Dude, like 80 plus percent of the guys in the NFL are on the juice.
They're on something." He's like, "It's just impossible not to." Whether something to enhance recovery, enhance strength, energy drive, whatever. I mean, all this stuff, it's not just steroids. There's a lot of performance-enhancing drugs. >> And I just thought like, you know, in one way, it would be cool to see a bunch of juiced up people basically maximizing whatever the human potential is. Obviously, there's negative negative consequences, too, for the people watching at home.
Um, and for athletes that are trying to do it in a fair way. So, I don't know. I I'm kind of interested. >> I mean, this is what the XFL was supposed to be, right? I mean, imagine if XFL was a bunch of juicers hitting each other.
uh you know the XFL that was released back in the '90s uh you know and then failed after a couple of years and then I think was recently just brought back again and now it's a little bit more spring league kind of you know that's I feel like that's what it should have been from the beginning you know this I I don't see anything like you've said I mean there's people these uh you know people play play football we know causes CTE you know has harmed a lot of people has caused a lot of traumatic brain injury uh people have suffered, died early, killed people, have had tragic episodes, you know, tragic early deaths in life.
So, I mean, people have been playing sports that endangers their life forever. I mean, from the gladiator days to now, uh, you know, so um this is just one iteration of that and I don't see a problem with consenting adults wanting to make a bunch of money putting their bodies on the line. I mean, they they understand that their life will be shortened. uh there's a big chance of getting cardiammyopathies, cardiac arhythmias, heart failure, heart attacks.
Uh you know that's big risk with a lot of these products especially when you're enhancing it. Uh and and then doing these high impact sports. Um and these are consenting adults. Uh they want to make money. People go to war to because they want to make money. People go, you know, do a lot of crazy stuff. >> And this is way Yeah. >> I mean, >> and you know, it's just interesting. I mean, not even just athletes.
I mean, there's a lot of people just dayto-day in the average population that take performance-enhancing substances. I mean, I see so many people in my orthopedic practice that come in for biceps ruptures, triceps ruptures, pectoralis tears, you know, Achilles injuries. These guys are just all in the juice. And you ask them, they're pretty forthcoming. They're like, "Yeah, I take steroids.
Yeah, I just finished my test cycle." And there's just a very very high rate of tendon injuries and tendon rupture because the muscle grows stronger and bigger and more powerful and more explosive when you take these substances. You work out more, you get stronger, your tendon and the junction of the muscle and tendon, the myotendon junction does not keep up. And there's a very very high rate of tendon and myotendon junction injuries in these kind of athletes.
But I'm just bringing that up because I see it every day. I mean there's so many people just your average people that just want to be jacked. They're not even athlete. they're taking steroids. So, I just think it's much more common than we think about it. And I don't know, maybe it's not as taboo as it used to be in society to be on some type of performance-enhancing drug. It kind of goes in line with the whole wellness space. >> Yeah.
The recent data has shown a lot of the different things in favor favor of hormone replacement therapy. >> You know, hormone replacement therapy is we know with a lot of strong evidence that it it is very safe. Uh it is actually very useful. a lot of patients and men and women should uh be be evaluated for hormone replacement therapy in the right way.
Um you know um there there was a there's a rise of these low tea clinics and that's kind of where my again the whole ethical stand idea of uh the provider that's injecting medication for you is is that provider uh profiting from the medication they're giving the patient and are they incentivized to give more and more? That's my problem with a lot of low low tea clinics. Uh but there's definitely a lot of good evidence behind testosterone replacement therapy.
You know, in terms of metabolic health, in terms of um muscle health, um you know, as you get older, testosterone levels do decrease. And it needs to be tested in the right way. I mean, there's a there's a whole idea of finding out if you have primary hypoganism or secondary hypoganism, right? You're supposed to check the right lab results. You're supposed to check your testosterone levels early in the morning.
Uh, and you have to have two different readings that show your testosterone levels to be low. You should be checking your FSH and LH levels as well to make sure it's not it's not secondary hypogonadism, right? Um, and if it's truly shows that you have low testosterone levels along with symptoms like erectile dysfunction or low sex drive, fatigue, low energy and a lot of other symptoms that come on with um, you know, low testosterone levels then is definitely indicated right.
So in people who in who uh um you know testosterone replacement therapy is indicated they definitely need it they benefit from it. Same thing with uh perrymenopausal women right uh the the perry menopausal symptoms are very significant they they cause a lot of effects a you know hot flashes get women to you know gain weight.
it can uh you know fasten their cardiovascular disease because the menopause and you know the lack of hormone that they're now not producing in their bodies has been used to and hormone replacement therapy has is shown to improve their side effects from par menopausal symptoms. So definitely there's indication for that but um the evidence has built up over time and and giving uh steroids performance enhancing drugs testosterone therapy unindicated we don't know what that means.
We don't know if someone who already has testosterone level of 800 900 and injecting more testosterone getting them to 2,00500 what that will do. We don't have enough data on that and we know that people who have had that um overdose of testosterone replacement therapy, hormone replacement therapy have suffered and have had heart attacks, have had strokes, uh have had hypertensive episodes.
So uh we have to be careful and you you wonder sometimes they say that this will be uh medically monitored but what physician and what type of physician will be monitoring them and who will >> talking about in the in the enhanced games? >> Yeah, in enhanced games. Yeah.
who will who will monitor uh these athletes and and what kind of advice will they give because there's no true evidence of um you know kind of you cannot practice evidence-based medicine and then tell them okay inject this performance-enhancing drug to optimize your your health. So who you you will have to cross some ethical boundaries to be able to advise these athletes right what what will you do if if one of your patients come in and be like hey Dr. be my be my uh physician for these games.
I will be participating in and advise me on this. What would you tell them? >> Gosh, I guess for me it's easy cuz I'm just a dumb bone doctor. I'd be like, yo, go to an endocrinologist. But I mean like joking aside, you know, I would be a bit torn mainly because I think the truthfully like the type of doctor that would get into that space and get involved with something like this and managing something in a non I guess like a non-medical way really.
This is just like performance enhancement so that these guys can compete and make money. You know, that's going to be more so along the lines of kind of what we were just talking about these people that are in regenerative and functional medicine because their practice is very different. It's not even really like a medical practice. It's more like a concurge service and consultation rather like a med spa.
You know, their clients come to them or they have video visits with them and you kind of give them what they want rather than what you think they need based on a diagnosis. Like there's no diagnosis here. >> Yeah. >> You know, like there's no treatment. You're just tailoring like a plan for them. Like it's like a diet plan just happens to be with injectable cocktails. >> Yeah.
Well, you know, you said you said the word diagnosis and uh that made me think of uh another story about diagnosis, which is >> Yeah, there you go. Good segue. >> One of the most interesting stories I've I've recently read. Very exciting and promising. >> This one's awesome. This is really >> Yeah, it kind of brings in like u you know, biochemistry and biology and AI kind of combines it >> and and Dr. Dittle little dog. >> Yeah, Dr. And this is a this is a story out of India in Karnataka.
Uh you know they did a study in six different hospitals on around 3,275 patients where they had dogs uh sniff uh uh these bags. They had people breathe into these these bags and sanitized bags and then have dogs sniff it and with almost 90% sensitivity dogs were able to predict if the patient had any signs of cancer, right? Any cancer cells present which is very interesting, right? Um Well, that's actually like crazy.
I mean, crazy how these dogs had 10 lead EEGs, 10 lead EEGs attached, which is producing um uh old like oldactory signals in the brain. Uh and AI they were able to use AI to assess and predict seven different types of cancer oral, breast, esophageal, cervical, lung, colurectal, and prostate cancer, which is which is amazing. I mean, you know, this is an amazing use of technology, AI, and something very cheap. I mean, the cost of this was ridiculous. I mean, very cheap dogs. >> Yeah.
It's like 50 bucks to get tested compared to like almost a,000 bucks for the so-called standard of care blood test for early detection. And it's better than the standard of care blood test for early detection by like a lot. >> Yeah. I mean you know uh just I said 90% sensitivity that means nine out of 10 early stage cancers were detected uh by this technology by dog sniffing it uh and and it blew my mind.
I mean I mean the the the thinking that went behind it this this company um you know is is it's called dognosis and they have a lot of different uses of this. >> I love the name too. Dognos I mean it's such a clever name dude. Yeah, >> it's easy to remember. But like, you know, while reading about this, we were talking about this a little offline. I mean, the the stats are absurd when you think about it.
Like the average human, you know, in the oldactory center, old faction meaning the smelling center. The average human in the old faction center of the brain has about six uh six million connections or neurons. But a dog in their old faction section has 300 million. I mean, like 300 million versus 6 million. I can't even fathom like how much of a dog's interaction with their world and their brain usage is based on smell and like how much more and like granular their sense of smell is than ours.
I mean it's absurd. Like you smell something nice like I don't know like peanut butter. I think everyone likes the smell of peanut butter as an example or like freshly cut grass or maple syrup whatever things that just smell objectively good and you're like oh wow that smell you recognize it you know and you recognize a smell you haven't smelt in a while. It kind of like lights up something in your brain. You know, a dog must feel like that 24/7.
I mean, their sense of smell is so sharp compared to ours. I mean, that's like probably the reason why they're so good at smelling even little cancer molecules. It's remarkable. >> Yeah. I mean, we've been using dogs for like kind of uh you know, their sense of smell for a lot of things like sniffing out drugs or finding prey or you know, um hunting >> even in the military like finding bombs and IEDs and stuff. >> Yeah, bombs, IDs.
This this I mean imagine dogs are one uh animal who we understand like we humans have spent the most time with dogs. We understand their their strength and sense of smell and what smelling what kind of skills they have and this company was able to harness that that that strength that the dogs have and to possibly produce a cancer detecting diagnosis where cancer can be detected very early. I mean uh what else can be done right? I mean imagine like how >> the possibilities, right?
>> How AI can be used to use that sense of smell for many different things and then also look at other animals and their strengths, right? Some some people have like some animals have amazing vision, right? Or sense of um uh sonar signaling, right? uh what can AI do using those signals to future in the future uh identify identify different patterns and then use that to predict things or visualize things. So I think I think the the possibilities are endless.
I mean I think the there's a whole space now that can use animal senses um to produce signals for AI to be able to predict things for us, right? He can use harness technology from animals, their skills, their strength, their uh their biological makeup to uh use it for human advancement. Uh >> yeah, and animals have been used like that for a long time. I mean, not just like lab mice, but I mean even in battle like elephants have been used in warfare, horses, cavalry, um even like bears.
Russia used bears during World War I to help carry like artillery shells apparently. And this is like a little bit I don't know how true this is, but this has been touted a lot that using whales or even dolphins um as like naval trainees um has been used. It's pretty crazy.
I mean, you know, one thing that I think is interesting about this though is like the applicability of something like this, like a dog sniffing mechanism because, you know, it took like a long time to train the dogs, like in some cases up to 18 months. 18 months is a long time. um you know and like how good the dog is and they they tested some specific dog breeds I think like beagles, Labradors. Um so it's still a question of like what specific dog breeds are there?
How long are you going to train them for the lifespan of the dog now?
because 18 months of training is quite a bit of investment um to do this and then what like HLA groups or phenotypes of humans like what races genders age groups human diets are very different that lead to different body odors different uh types of cancer all the different subtypes you know like there's not just esophageal cancer there's so many different types and subtypes of that that have different uh compounds so like for the dog to smell and detect everything like this is an early stage study It's still in a trial phase and it's very promising and I think it's awesome.
But, you know, these are all factors that could be potential, not necessarily limiters to this use, but it could kind of dampen how broad and widespread the utilization of something like this becomes. >> Yeah. I mean, this is far off from like you know uh any kind of mainstream use. Uh there's early phase data showing some promise and I think it needs to be advanced more and and developed more.
uh but it opens up a lot of possibilities and once there is initial uh initial um you know case use then it can build on that and you know kind of build like a lot of uh third world countries a lot of subsaharan um countries or Asian countries uh uh countries that don't have the same healthcare facilities I mean uh and the cost are high cannot get a simple mamogram or a chest CT for lung cancer screening uh a colonoscopy or or endoscopy to detect certain types of cancer, right?
I mean, and lifespans are much shorter. I mean, now if this is available, I can detect nine out of 10 early cancers, diagnosis can be much faster in some of the patients or maybe even um a much cheaper early treatment, right?
I mean if if someone just has some early diagnosis of colon cancer that can be detected they can actually get a colonoscopy it can be indicated and they they would be willing to kind of you can you can standardize colonoscopy for those patients in in those resource limited countries. >> Yeah you could intervene earlier and yeah definitely >> you could intervene earlier. So I think the possibilities are endless.
I mean you know I think in a country like United States where u you know everything is so profit driven and healthcare has become like a money-m uh machine uh where CTS and mamogs and you know uh advanced blood tests are so prevalent where people you know insuranceances Medicare all that are willing to pay for it yeah maybe it'll be slow to adopt slow to take over but in a lot of other countries I think this could have a lot of uh uh you know a lot of use applications so for Sure.
I could also see like some regulatory red tape like you know like to make this applicable on mass scale you'd have to have like a giant farm of just like thousands of dogs sitting there here smell this smell this you know like that could that's definitely like something that's going to get the animal rights folks freaked out like PETA is going to lose their mind on this you know dognosis is going to be public enemy number one. >> Yeah. I mean maybe you know Yeah.
I mean you know dogs life matters and >> Right. Right. Right. DM, baby. DM. >> Yeah. I mean, you'll be people will be able to donate their pets, you know? I mean, you can this can be a job in the AI era, right? Where when a lot of people are losing their jobs, you can be a dog trainer at home that that trains a diagnosis dog uh and and take care of them and and have them be available for testing when they need to. So, I mean, yeah, you don't have to have mass farms.
You can have certain jobs and assign to people and people can, you know, people always love having dogs anyways. So, and then maybe they can get paid for it as well. And and so the just like you know they can they can have five dogs and they can be training five dogs and have own small businesses of dog training. So the possibilities are endless. But >> decentralize it a bit. >> Yeah.
Imagine but imagine what we can do with um you know for example like eagles or uh you know some someone who's known for their vision or >> you know animals that can like uh find prey from from top of water inside water and catch fish that way. um who have certain senses that we don't know and we can't have not harnessed yet and and using now animal sensory uh you know um sensory sense animal senses to kind of harness that and use it for our advantage can be a big deal. So very exciting.
Um you know >> it is cool. It's really it's really cool. I think it's like a very ingenious thing to using something that already exists, just repurpose it. Like dogs already smell like freaking amazing, make them smell cancer. That's such a like simple of a genius idea. >> Yeah. I mean, humans have been, you know, kind of accomplishing a lot of amazing things.
And I mean, the past 150 years or even past 100 years of innovation has led us to like, you know, a lot of these amazing discovery and now we're in the age of AI.
Uh but space is also a very interesting topic and we just recently had the Artemis 2 >> uh launch where a bunch of people went to and it kind of made me think you know we're talking about the the the the human body and what people have done to optimize the human body but space has can have a lot of impact on the human body as well and there's been many experiments or even twins going into space you know one twin goes into space and uh >> and the other twin brother yeah and then and they they can compare there and see like you know what were the changes so I know you have a lot to say of that this this is your your area of expertise uh and the effect of space on the human body um so this is um you know >> yeah it's I mean it's super interesting I I would never claim to be an expert I mean I I do work with like the center for space medicine and NASA regarding this stuff and like you know mainly this was a 10-day mission okay and that's what a lot of these missions are the whole shuttle program Um, and now our whole goal with NASA to go back to the moon and then in the next several years return again and actually land on the lunar surface and walk >> back to the moon.
What do you mean go back to the moon? >> Back to the moon, baby. >> Yeah, we went in the first place. Do you believe that? >> I like it. The conspiracy the moon landing. But yes, um, but anyways, you know, like in this whole back to the moon thing. Yes, back to the moon. Um, what are the changes that are going to happen with prolonged time in space flight and in microgravity?
What's going to happen to the human body when you're in space with almost no gravity for one, a lot more radiation for two cuz you're outside of the Earth's magnetosphere? Um, you don't have the resistive forces on the muscles in the skeleton, the changes in fluid shifts. I mean, there's so much stuff that changes in space like vision across the board decreases in space. Your optic nerve gets ademinus in space. So astronauts have vision changes who were otherwise they had perfect vision in space.
That happens to many many astronauts. Your immune system in general doesn't work as well in space because your immune cells cannot home in and extravate meaning leave the blood vessels and get to the site of an infection or even an injury in space.
So in fact these healthy astronauts I mean traditionally astronauts were much more uh commonly men and now there's a lot more females too but in the early days of the astronauts in the early shuttle missions these you know males in their late 30s early 40s and overall very healthy group it would be unheard of for a human on Earth who's 35 to 40 years old a human male to get a UTI it just doesn't happen >> like almost 40 50% of the astronauts were getting UTI which is crazy and it's because the immune immune system wasn't working.
Simultaneously, even crazier is that pathogens, bacteria, actually increase their pathogenicity and their virilance factors in space. Something about the microgravity environment enhances that, which now you're getting hit from both sides. Your immune system gets depressed and bacteria increase their ability to cause and create an infection. The cardiovascular effects are tremendous because all your fluid without gravity, you get a sephilad or a cranial shift in the fluid.
So, it's an increased demand and load on the heart. Now you also get like increased like a ton of headaches and pressure in the head and then all the muscular skeletal changes. You lose bone density in space. You lose muscle mass in space. You have a lot of rotator cuff and laboral injuries in space. You know that's something we've published on is that astronauts have a disproportionate rate of injuries in space to their shoulder girdle because you can't walk in space.
Everything is you grab and propel, grab and propel and that's not what the shoulder and the rotator cuff were designed to do. Um these are just like a little sampling of stuff. So many things happen in space and these astronauts that are aboard the ISS the space station for like 6 months at a time.
So now if you're thinking of like what NASA is talking about and actually planning in the Artemis 3 and Artemis 4 missions like a lunar base and then further to go to Mars and even establish a longerterm colony on Mars or even going to Mars is like an a year and a half mission. Um you have to have contingencies for this stuff because what do you do if someone has a severe infection in space? You don't have the ability to get imaging. You don't have the ability to get real labs in space.
I mean, the ability to confirm diagnosis is severely limited. The ability to treat like how much stuff do you take with you? And is that stuff going to work the same in the absence of normal gravity versus how it does on Earth? What if someone breaks a bone in space? Can a fracture even heal in space in the absence of gravity and the normal forces on the bone? How are you going to set it? How are you going to manage that person?
Now they've become a liability because every single thing, every person when you go into space, every kilogram is accounted for. Everything is mission critical. You don't have any spare capacity. So there there's so many factors that are huge question marks like for NASA, for commercial space flight, for everybody that are still unanswered. >> Yeah, I think this is where I think you know the one guy that comes into mind when you talk about space is Elon Musk.
I mean his sole sole mission in life is to make human beings interplanetary species, right? Um SpaceX now uh you know if you just heard the news, SpaceX uh so he has this company called XAI, right? Uh and XAI just got merged with SpaceX. Now a lot of it was done for the IPO reason. SpaceX was going to go IPO and needed mass funding uh because of the initial public offering. So he combined his AI uh company with SpaceX as well.
Um but I can see that as a play in the future where also u you know uh Musk is working through Tesla on Optimus uh which is I think it's called Optimus. I I forgot the name. Yeah, Optimus for >> uh correct me if I'm wrong on the name. I might be >> forgetting. I think it is Optimus. But I I'm also like very surprised that somehow that wasn't trademarked by like Hasbro and the Transformers. >> Yeah. Yeah. So he's yeah that's that's why I'm having doubts. I was like was it not trademark?
Yeah but he is working on the optimist and and uh apparently these these these robots are very smart and they they are using a lot of the artificial intelligence through X AI in them and they they can understand things and have uh you know bodies that can be very agile.
Now you wonder like you know starting off if if the goal is to get on get on get to Mars and be interplanetary species and space travel and space being in space can be such a such a huge burden on the human body is it even possible for human body to get to Mars and and survive that long mission all the way there and as the gravitational pole gets lower and lower um you know the effects will get get much harder as well so um you know that has to have played in in Elon's mind where these optimist models uh with their artificial intelligence will be what build those colonies of Mars and Moon base in the future where they can go and build the colonies for eventually humans to come in and and then um kind of inhabit.
Right. Sometime it makes me wonder that if that's part of the plan. I don't know if he's explicitly came out and said that. >> It's a cool idea. I mean, yeah, basically get the robots to build it and then we just go. Um, obviously there's still consequences of that duration of travel and Mars gravity is different and even, you know, like there's so many unanswered questions.
I think it's so fascinating to think about because everything we know about the human body is it's actually what we know about the human body on Earth. We don't know about the human body anywhere other than Earth. And I mean, can humans even procreate? Can a child even be born outside of the Earth exact millu of environmental factors? Like is it even possible for a fetus to develop if you don't have the normal gravitational forces on it?
Because I mean you remember from developmental biology it starts off as just like a wad of cells and the alignment and change of the cells and how they grow and expand in certain areas and not in others is critically dependent on like signaling pathways different axes of development. The psyia the little micro hairs how they guide molecules all of that stuff has very much to do with gravity.
If gravity's eliminated, the fluid shifts and stuff within the uterus, within the womb, the blood flow, umbilical arteries and all that stuff. I mean, no one knows the answer to this stuff. >> Um, it hasn't. >> If you believe, if you believe in evolution, I mean, human bodies are the way they are. Our body structure, our cells, our organs are the way they are because we're on Earth. Not we're on Earth and because, you know, that's if if that's >> Yeah, we've adapted to Earth.
>> We've adapted to Earth, right? And and our bodies are this way. Our cells work this way because we live on Earth. And when we move on to Mars and other other planets, will our bodies be able to like, you know, function? And that's why I think we'll have to recreate these same exact conditions on the moving on Mars if we want to be interplanetary species.
And for that, you'll have to have something that's more um you know um can survive those conditions like robots with artificial intelligence to build those environments for us first.
Uh and then >> yeah I think you know it's funny like in that idea of terraforming like you know creating an environment similar to earth on a different planet Elon he said like you know he says a lot of outlandish stuff but obviously the guy delivers in terms of the success of a lot of his ventures he talked about like in one thing like just purposely detonating thermonuclear weapons on the poles of Mars to create like some cataclysmic effect and like a warming and melting the poles and creating running water and all this And like that would be a rapid way to help terraform and get plants eventually and all this stuff and oxygen ratios would increase and like just just nuke Mars, huh?
That's the plan. >> I mean that's that's the plan. It's a constant nuclear reaction on Mars that creates a sunlike uh sunlike object that you know produces heat and uh energy for for Mars. So it's I mean this guy I mean he you know no matter what you think of Elon and you know he has a lot of crazy ideas. He has says a lot of crazy stuff but you know he has a goal. He's one he's one minded. I mean his goal is for humans to be interplanetary species.
Everything else he does is is to enhance and expedite that goal, right? Uh and every all his companies he thinks that's his final mission and that's what he wants to be known for.
and he for all his all his quirks uh he has delivered a lot of great things a lot of innovation um which which and this is the next frontier for him I mean I mean he's getting there and you know >> oh no doubt I mean he's he's a true mad scientist like that's that's for sure >> he's truly mad >> but you know what what I think is fascinating in all this stuff regarding space and like people talking about the future of space and long-term plans and all so much of it especially the commercial space flight guys like These rich guys like Bezos and Branson and Musk, none of them at all talk about or focus on or are devoting their research to the changes in human physiology and the biological changes in space.
All of them are just kind of in a contest with each other to have another rocket that goes to space, be the one that takes the astronauts up in the Dragon capsule, you know, the one that is contract with the ISS. All of it is based on the engineering and the physics and the rocket technology. But really what's our actual rate limiting step is not how much fire we can burn from a metal cylinder. You know like we've understood the rockets like and rocket technology will continue to improve.
There hasn't been any breakthrough in countermeasures for the changes to human physiology and that's going to be the biggest rate limiting thing and that's hard to address because that is is what takes real long-term studies and real science and it's very hard to do because your sample size will always be tiny in space. How do you address that? And no one is looking at that in in very much detail.
That's why, you know, I think the budget cuts that have happened to NASA are catastrophic because with this stated goal of making humans an interplanetary species living outside of Earth or having the ability to live outside of Earth, yet you're cutting funding to the one institution that actually is devoting money to researching human biology and its changes in space. You're you're counteracting that goal.
>> Well, there's been a lot of big rise in a lot of private companies, right, who are working a lot of different spaces. A lot of >> Yeah, but that's what I'm saying. None of them, none of them are looking at that human biology side to this extent.
They can't because to run an experiment on astronauts, you've got to have approval and funding that goes through NASA and you've got to have the study done, you know, on the ISS, the International Space Station, because these little rocket missions that are shot up, they're not long-term enough to really give you any meaningful data. You've got to do it in a long-term setting, and that setting is the International Space Station. >> Yeah.
and um and and maybe their argument is that once first we have to get there properly and be able to stay there and come back to for us to do any further human studies and trials uh and to learn more about it. But there's a lot of things we can do here to recreate those those those because we know enough about the conditions and they can be recreated on Earth to kind of study that, right? >> Kind of. Yeah.
Yeah, I mean there's analog models for attempting to recreate some stuff like bed rest studies, you know, but like these are all surrogate environments and none of them are really that representative because like a bed rest study, yeah, you'll get muscle and bone loss, but you're not going to get all the other effects and the astronauts are not in bed rest. They're actively doing stuff despite muscle and bone loss.
You know, like I agree with you, there are analog models because that's the best we have, but they're not the real thing. >> They're not the real thing. you know, just like, you know, the whole theme, the amazingness of the human body, the human mind, uh, dogs, and, uh, you know, I think we're going to continue, uh, advancing as a human race, and, uh, you know, uh, we'll continue talking about it on Two Dogs, One Mic. >> There you go, baby. All right, >> we'll catch you all next time. Excel.